ARF6

ARF6 — (ing. ADP ribosylation factor 6) 14-cü xromosomun qısa qolunda insanlarda tapılan tək gen tərəfindən kodlanmış zülal. Zülalın polipeptid zəncirinin uzunluğu 175 amin turşusu, molekulyar çəkisi isə 20.082-dir.

ARF6
Mövcud strukturlar Ortoloq axtarışı: PDBe RCSB PDB id kodlarının siyahısı 1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Tanımlayıcılar
	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
Xarici ID-lər	600464 99435 1256 ARF6
Genin yeri (İnsan) Xromosom Lokus 14q21.3 Başlanğıc 49,893,079 Son 49,897,054
Genin yeri (Siçan) Xromosom Xromosom 12 (siçan) Lokus 12|12 C2 Başlanğıc 69,418,924 Son 69,420,557
İfadə məlumatı üçün daha çox istinad
Molekulyar funksiya • nucleotide binding • protein N-terminus binding • GTP binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • thioesterase binding Hücrəsəl komponent • Sitoplazma • recycling endosome • endosome • Holci kompleksi • cell projection • membrane • focal adhesion • ruffle • myelin sheath • Membran • endocytic vesicle • intracellular anatomical structure • cell cortex • early endosome • endosome membrane • extracellular exosome • filopodium membrane • recycling endosome membrane • cleavage furrow • cytosol • Flemming body • early endosome membrane • presynapse • glutamatergic synapse Bioloji proses • establishment of epithelial cell polarity • cell differentiation • regulation of filopodium assembly • positive regulation of actin filament polymerization • ruffle organization • small GTPase mediated signal transduction • regulation of Rac protein signal transduction • nervous system development • negative regulation of dendrite development • Hüceyrənin bölünməsi • negative regulation of receptor-mediated endocytosis • cell adhesion • protein localization to cell surface • protein transport • protein localization to endosome • cell cycle • liver development • myeloid cell apoptotic process • GO:0033109 cortical actin cytoskeleton organization • vesicle-mediated transport • regulation of dendritic spine development • hepatocyte apoptotic process • GO:0015915 transport • positive regulation of protein localization to plasma membrane • intracellular protein transport • regulation of neuron projection development • endocytic recycling • synaptic vesicle endocytosis • positive regulation of keratinocyte migration • ruffle assembly • maintenance of postsynaptic density structure • positive regulation of adherens junction organization • regulation of presynapse assembly • cellular response to nerve growth factor stimulus • negative regulation of protein localization to cell surface • positive regulation of protein secretion • positive regulation of protein homodimerization activity Sources:Amigo / QuickGO
Species	Human	Mouse
	382	11845
	ENSG00000165527	ENSMUSG00000044147
UniProt	P62330	P62331
RefSeq (mRNA)	NM_001663	NM_007481
RefSeq (protein)	NP_001654	NP_031507
Yeri (UCSC)	Chr 14: 49.89 – 49.9 Mb	Chr 12: 69.42 – 69.42 Mb
axtarışı
Wikidata
İnsanı göstər/redaktə et Siçanı göstər/redaktə et

ARF6 çox vaxt bioloji membranların və transmembran protein yüklərinin daşınmasında iştirak edən çoxlu hüceyrə funksiyalarına malikdir. ARF6 xüsusi olaraq plazma membranı zülallarının endositozunda və həmçinin daha az dərəcədə plazma membranı zülallarının təkrar emalında iştirak edir.

Funksiyası

Bu gen, Ras super ailəsinin bir hissəsi olan insan ARF gen ailəsinin bir üzvünü kodlaşdırır.

ARF genləri vəba toksininin ADP-ribosiltransferaza fəaliyyətini stimullaşdıran və vezikulyar ticarətdə və fosfolipaz D-nin aktivatoru kimi rol oynayan kiçik guanin nukleotid bağlayan zülalları kodlayır. Bu genin məhsulu plazma membranında lokallaşdırılır və vezikulyar daşınma, membranın lipidlərinin yenidən qurulması və aktiniumun yenidən qurulmasına səbəb olan siqnal yollarını tənzimləyir. Bu genin psevdogeni 7-ci xromosomda yerləşir.

ARF6 reseptorların aktivləşdirilməsindən sonra βarrestin ilə qarşılıqlı təsir göstərə bilər.

Qarşılıqlı əlaqələri

ARF6-nın aşağıdakılarla qarşılıqlı əlaqədə olduğu göstərilmişdir:

• Arrestin beta 1
• ARFIP2
• CHRM3
• EXOC5
• KIAA0090
• Rac1

İstinadlar

1. GRCh38: Ensembl release 89: ENSG00000165527 - , May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044147 - , May 2017
3. "Human PubMed Reference:".
4. "Mouse PubMed Reference:".
5. "HUGO Gene Nomenclature Commitee, HGNC:659" (англ.). İstifadə tarixi: 11 вересня 2017.^{[ölü keçid]}
6. [nhttps://en.wikipedia.org/wiki/Ras_superfamily "Arxivlənmiş surət"]. 2023-02-19 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
7. "Entrez Gene: ARF6 ADP-ribosylation factor 6".
8. "Arxivlənmiş surət". 2023-05-21 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
9. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45). November 2001: 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.
10. D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
11. Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
12. Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS. "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36). September 2003: 33818–30. doi:10.1074/jbc.M305825200. PMID 12799371.
13. Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P. "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector". J. Cell Biol. 163 (5). December 2003: 1111–21. doi:10.1083/jcb.200305029. PMC 2173613. PMID 14662749.
14. Prieto C, De Las Rivas J. . Nucleic Acids Res. 34 (Web Server issue). July 2006: W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013. 2010-04-09 tarixində orijinalından arxivləşdirilib.
15. Peru y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A. "Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B". J. Neurosci. 32 (49). December 2012: 17706–13. doi:10.1523/JNEUROSCI.1944-12.2012. PMC 3535434. PMID 23223291.

Ədəbiyyatı

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