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Arrestin beta 1 ARRB1 kimi də adlanır insanlarda 11 ci xromosomun qısa qolunda olan tək bir gen tərəfindən kodlanmış zül

Arrestin beta 1

Arrestin beta 1
www.wikimedia.az-az.nina.azhttps://www.wikimedia.az-az.nina.az

Arrestin beta 1 ARRB1 kimi də adlanır — insanlarda 11-ci xromosomun qısa qolunda olan tək bir gen tərəfindən kodlanmış zülal.

Arrestin beta 1
Tanımlayıcılar
ARRB1non-visual arrestin-2beta-arrestin-1Arrestin beta-1arrestin 2
Xarici ID-lər [1]
SpeciesHumanMouse

n/a

n/a

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Yeri (UCSC)n/an/a
axtarışın/an/a
Wikidata
İnsanı göstər/redaktə et

Funksiyası

Beta-arrestin zülal ailəsinin üzvlərinin G zülalı ilə əlaqəli reseptorların agonist vasitəçiliyi ilə desensitizasiyasında iştirak etdiyi və hormonlar, neyrotransmitterlər və ya duyğu siqnalları kimi stimullara hüceyrə reaksiyalarının spesifik şəkildə yatırılmasına səbəb olduğu düşünülür.

Arrestin beta 1 sitozolik zülaldır və beta-adrenergik reseptorların beta-adrenergik reseptor kinaz (BARK) vasitəçiliyi ilə desensibilizasiyasında kofaktor kimi çıxış edir.

Arrestin beta 1 mərkəzi sinir sistemi ilə yanaşı, periferik qan leykositlərində yüksək səviyyədə ifadə edilir və beləliklə, BARK/beta-arrestin sisteminin reseptor vasitəçiliyi ilə immun funksiyalarının tənzimlənməsində böyük rol oynadığına inanılır.

Alternativ olaraq, arrestin beta 1-in müxtəlif izoformlarını kodlayan birləşdirilmiş transkriptlər təsvir edilmişdir, lakin onların dəqiq funksiyaları məlum deyil. Beta-arrestinin aralıq maddələri birləşdirən və reseptorları klatrin vasitəçiliyi ilə endositoza birləşdirərək G-protein siqnalını yönləndirə bilən bir çərçivə rolunu oynadığı göstərilir.

Qarşılıqlı əlaqələri

Arrestin beta 1 ilə qarşılıqlı əlaqədə olanlar:

  • ARF6,
  • PTHLH,
  • DVL2
  • Mdm2,
  • OPRD1,
  • PSCD2, və
  • RALGDS.

İstinadlar

  1. Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A. "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13). May 1993: 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.
  2. "Entrez Gene: ARRB1 arrestin, beta 1". 2010-12-05 tarixində . İstifadə tarixi: 2023-09-19.
  3. "Arxivlənmiş surət". 2023-08-19 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
  4. "Arxivlənmiş surət". 2023-07-11 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
  5. Peterson YK, Luttrell LM. "The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling". Pharmacological Reviews. 69 (3). July 2017: 256–297. doi:10.1124/pr.116.013367. PMC 5482185. PMID 28626043.
  6. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". The Journal of Biological Chemistry. 276 (45). November 2001: 42509–42513. doi:10.1074/jbc.M108399200. PMID 11533043.
  7. Conlan LA, Martin TJ, Gillespie MT. "The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B". FEBS Letters. 527 (1–3). September 2002: 71–75. doi:10.1016/S0014-5793(02)03164-2. PMID 12220636.
  8. Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proceedings of the National Academy of Sciences of the United States of America. 98 (26). December 2001: 14889–14894. Bibcode:2001PNAS...9814889C. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073.
  9. Wang P, Wu Y, Ge X, Ma L, Pei G. "Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus". The Journal of Biological Chemistry. 278 (13). March 2003: 11648–11653. doi:10.1074/jbc.M208109200. PMID 12538596.
  10. Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM. "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor". The Journal of Biological Chemistry. 283 (32). August 2008: 22166–22176. doi:10.1074/jbc.M709668200. PMC 2494938. PMID 18544533.
  11. Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, və b. "Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor". Journal of Neurochemistry. 76 (6). March 2001: 1887–1894. doi:10.1046/j.1471-4159.2001.00204.x. PMID 11259507.
  12. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, və b. "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nature Cell Biology. 4 (8). August 2002: 547–555. doi:10.1038/ncb821. PMID 12105416.

Ədəbiyyatı

  • Lefkowitz RJ. "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization". The Journal of Biological Chemistry. 273 (30). July 1998: 18677–18680. doi:10.1074/jbc.273.30.18677. PMID 9668034.
  • Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. "beta-Arrestin: a protein that regulates beta-adrenergic receptor function". Science. 248 (4962). June 1990: 1547–1550. Bibcode:1990Sci...248.1547L. doi:10.1126/science.2163110. PMID 2163110.
  • Calabrese G, Sallese M, Stornaiuolo A, Morizio E, Palka G, De Blasi A. "Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13". Genomics. 24 (1). November 1994: 169–171. doi:10.1006/geno.1994.1594. PMID 7896272.
  • Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A. "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13). May 1993: 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.
  • Iacovelli L, Franchetti R, Masini M, De Blasi A. "GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response". Molecular Endocrinology. 10 (9). September 1996: 1138–1146. doi:10.1210/mend.10.9.8885248. PMID 8885248.
  • Bonaldo MF, Lennon G, Soares MB. "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9). September 1996: 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Goodman OB, Krupnick JG, Gurevich VV, Benovic JL, Keen JH. "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain". The Journal of Biological Chemistry. 272 (23). June 1997: 15017–15022. doi:10.1074/jbc.272.23.15017. PMID 9169477.
  • Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1". The Journal of Biological Chemistry. 272 (49). December 1997: 31051–31057. doi:10.1074/jbc.272.49.31051. PMID 9388255.
  • Aragay AM, Mellado M, Frade JM, Martin AM, Jimenez-Sainz MC, Martinez-A C, Mayor F. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2". Proceedings of the National Academy of Sciences of the United States of America. 95 (6). March 1998: 2985–2990. Bibcode:1998PNAS...95.2985A. doi:10.1073/pnas.95.6.2985. PMC 19681. PMID 9501202.
  • ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker". Cell. 95 (4). November 1998: 563–573. doi:10.1016/S0092-8674(00)81623-2. PMC 4428171. PMID 9827808.
  • Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, və b. "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes". Science. 283 (5402). January 1999: 655–661. doi:10.1126/science.283.5402.655. PMID 9924018.
  • McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. "Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation". The Journal of Biological Chemistry. 274 (16). April 1999: 10677–10680. doi:10.1074/jbc.274.16.10677. PMID 10196135.
  • Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. "Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases". The Journal of Biological Chemistry. 274 (23). June 1999: 15971–15974. doi:10.1074/jbc.274.23.15971. PMID 10347142.
  • McConalogue K, Déry O, Lovett M, Wong H, Walsh JH, Grady EF, Bunnett NW. "Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor". The Journal of Biological Chemistry. 274 (23). June 1999: 16257–16268. doi:10.1074/jbc.274.23.16257. PMID 10347182.
  • Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. "beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis". The Journal of Biological Chemistry. 275 (15). April 2000: 11312–11319. doi:10.1074/jbc.275.15.11312. PMID 10753943.
  • Laporte SA, Oakley RH, Holt JA, Barak LS, Caron MG. "The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits". The Journal of Biological Chemistry. 275 (30). July 2000: 23120–23126. doi:10.1074/jbc.M002581200. PMID 10770944.
  • Bennett TA, Maestas DC, Prossnitz ER. "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence". The Journal of Biological Chemistry. 275 (32). August 2000: 24590–24594. doi:10.1074/jbc.C000314200. PMID 10823817.
  • Shiina T, Kawasaki A, Nagao T, Kurose H. "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors". The Journal of Biological Chemistry. 275 (37). September 2000: 29082–29090. doi:10.1074/jbc.M909757199. PMID 10862778.
  • Barlic J, Andrews JD, Kelvin AA, Bosinger SE, DeVries ME, Xu L, və b. "Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI". Nature Immunology. 1 (3). September 2000: 227–233. doi:10.1038/79767. PMID 10973280.
  • Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, və b. "Visualization of arrestin recruitment by a G-protein-coupled receptor". Nature. 512 (7513). August 2014: 218–222. Bibcode:2014Natur.512..218S. doi:10.1038/nature13430. PMC 4134437. PMID 25043026.

Xarici keçidlər

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Arrestin beta 1 ARRB1 kimi de adlanir insanlarda 11 ci xromosomun qisa qolunda olan tek bir gen terefinden kodlanmis zulal Arrestin beta 1TanimlayicilarARRB1non visual arrestin 2beta arrestin 1Arrestin beta 1arrestin 2Xarici ID ler 1 SpeciesHumanMousen an an an aUniProtn an aRefSeq mRNA n an aRefSeq protein n an aYeri UCSC n an aaxtarisin an aWikidataInsani goster redakte etFunksiyasiBeta arrestin zulal ailesinin uzvlerinin G zulali ile elaqeli reseptorlarin agonist vasiteciliyi ile desensitizasiyasinda istirak etdiyi ve hormonlar neyrotransmitterler ve ya duygu siqnallari kimi stimullara huceyre reaksiyalarinin spesifik sekilde yatirilmasina sebeb oldugu dusunulur Arrestin beta 1 sitozolik zulaldir ve beta adrenergik reseptorlarin beta adrenergik reseptor kinaz BARK vasiteciliyi ile desensibilizasiyasinda kofaktor kimi cixis edir Arrestin beta 1 merkezi sinir sistemi ile yanasi periferik qan leykositlerinde yuksek seviyyede ifade edilir ve belelikle BARK beta arrestin sisteminin reseptor vasiteciliyi ile immun funksiyalarinin tenzimlenmesinde boyuk rol oynadigina inanilir Alternativ olaraq arrestin beta 1 in muxtelif izoformlarini kodlayan birlesdirilmis transkriptler tesvir edilmisdir lakin onlarin deqiq funksiyalari melum deyil Beta arrestinin araliq maddeleri birlesdiren ve reseptorlari klatrin vasiteciliyi ile endositoza birlesdirerek G protein siqnalini yonlendire bilen bir cercive rolunu oynadigi gosterilir Qarsiliqli elaqeleriArrestin beta 1 ile qarsiliqli elaqede olanlar ARF6 PTHLH DVL2 Mdm2 OPRD1 PSCD2 ve RALGDS IstinadlarParruti G Peracchia F Sallese M Ambrosini G Masini M Rotilio D De Blasi A Molecular analysis of human beta arrestin 1 cloning tissue distribution and regulation of expression Identification of two isoforms generated by alternative splicing The Journal of Biological Chemistry 268 13 May 1993 9753 9761 doi 10 1016 S0021 9258 18 98412 7 PMID 8486659 Entrez Gene ARRB1 arrestin beta 1 2010 12 05 tarixinde Istifade tarixi 2023 09 19 Arxivlenmis suret 2023 08 19 tarixinde arxivlesdirilib Istifade tarixi 2023 09 19 Arxivlenmis suret 2023 07 11 tarixinde arxivlesdirilib Istifade tarixi 2023 09 19 Peterson YK Luttrell LM The Diverse Roles of Arrestin Scaffolds in G Protein Coupled Receptor Signaling Pharmacological Reviews 69 3 July 2017 256 297 doi 10 1124 pr 116 013367 PMC 5482185 PMID 28626043 Claing A Chen W Miller WE Vitale N Moss J Premont RT Lefkowitz RJ beta Arrestin mediated ADP ribosylation factor 6 activation and beta 2 adrenergic receptor endocytosis The Journal of Biological Chemistry 276 45 November 2001 42509 42513 doi 10 1074 jbc M108399200 PMID 11533043 Conlan LA Martin TJ Gillespie MT The COOH terminus of parathyroid hormone related protein PTHrP interacts with beta arrestin 1B FEBS Letters 527 1 3 September 2002 71 75 doi 10 1016 S0014 5793 02 03164 2 PMID 12220636 Chen W Hu LA Semenov MV Yanagawa S Kikuchi A Lefkowitz RJ Miller WE beta Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins Proceedings of the National Academy of Sciences of the United States of America 98 26 December 2001 14889 14894 Bibcode 2001PNAS 9814889C doi 10 1073 pnas 211572798 PMC 64954 PMID 11742073 Wang P Wu Y Ge X Ma L Pei G Subcellular localization of beta arrestins is determined by their intact N domain and the nuclear export signal at the C terminus The Journal of Biological Chemistry 278 13 March 2003 11648 11653 doi 10 1074 jbc M208109200 PMID 12538596 Shenoy SK Xiao K Venkataramanan V Snyder PM Freedman NJ Weissman AM Nedd4 mediates agonist dependent ubiquitination lysosomal targeting and degradation of the beta2 adrenergic receptor The Journal of Biological Chemistry 283 32 August 2008 22166 22176 doi 10 1074 jbc M709668200 PMC 2494938 PMID 18544533 Cen B Yu Q Guo J Wu Y Ling K Cheng Z ve b Direct binding of beta arrestins to two distinct intracellular domains of the delta opioid receptor Journal of Neurochemistry 76 6 March 2001 1887 1894 doi 10 1046 j 1471 4159 2001 00204 x PMID 11259507 Bhattacharya M Anborgh PH Babwah AV Dale LB Dobransky T Benovic JL ve b Beta arrestins regulate a Ral GDS Ral effector pathway that mediates cytoskeletal reorganization Nature Cell Biology 4 8 August 2002 547 555 doi 10 1038 ncb821 PMID 12105416 EdebiyyatiLefkowitz RJ G protein coupled receptors III New roles for receptor kinases and beta arrestins in receptor signaling and desensitization The Journal of Biological Chemistry 273 30 July 1998 18677 18680 doi 10 1074 jbc 273 30 18677 PMID 9668034 Lohse MJ Benovic JL Codina J Caron MG Lefkowitz RJ beta Arrestin a protein that regulates beta adrenergic receptor function Science 248 4962 June 1990 1547 1550 Bibcode 1990Sci 248 1547L doi 10 1126 science 2163110 PMID 2163110 Calabrese G Sallese M Stornaiuolo A Morizio E Palka G De Blasi A Assignment of the beta arrestin 1 gene ARRB1 to human chromosome 11q13 Genomics 24 1 November 1994 169 171 doi 10 1006 geno 1994 1594 PMID 7896272 Parruti G Peracchia F Sallese M Ambrosini G Masini M Rotilio D De Blasi A Molecular analysis of human beta arrestin 1 cloning tissue distribution and regulation of expression Identification of two isoforms generated by alternative splicing The Journal of Biological Chemistry 268 13 May 1993 9753 9761 doi 10 1016 S0021 9258 18 98412 7 PMID 8486659 Iacovelli L Franchetti R Masini M De Blasi A GRK2 and beta arrestin 1 as negative regulators of thyrotropin receptor stimulated response Molecular Endocrinology 10 9 September 1996 1138 1146 doi 10 1210 mend 10 9 8885248 PMID 8885248 Bonaldo MF Lennon G Soares MB Normalization and subtraction two approaches to facilitate gene discovery Genome Research 6 9 September 1996 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Goodman OB Krupnick JG Gurevich VV Benovic JL Keen JH Arrestin clathrin interaction Localization of the arrestin binding locus to the clathrin terminal domain The Journal of Biological Chemistry 272 23 June 1997 15017 15022 doi 10 1074 jbc 272 23 15017 PMID 9169477 Lin FT Krueger KM Kendall HE Daaka Y Fredericks ZL Pitcher JA Lefkowitz RJ Clathrin mediated endocytosis of the beta adrenergic receptor is regulated by phosphorylation dephosphorylation of beta arrestin1 The Journal of Biological Chemistry 272 49 December 1997 31051 31057 doi 10 1074 jbc 272 49 31051 PMID 9388255 Aragay AM Mellado M Frade JM Martin AM Jimenez Sainz MC Martinez A C Mayor F Monocyte chemoattractant protein 1 induced CCR2B receptor desensitization mediated by the G protein coupled receptor kinase 2 Proceedings of the National Academy of Sciences of the United States of America 95 6 March 1998 2985 2990 Bibcode 1998PNAS 95 2985A doi 10 1073 pnas 95 6 2985 PMC 19681 PMID 9501202 ter Haar E Musacchio A Harrison SC Kirchhausen T Atomic structure of clathrin a beta propeller terminal domain joins an alpha zigzag linker Cell 95 4 November 1998 563 573 doi 10 1016 S0092 8674 00 81623 2 PMC 4428171 PMID 9827808 Luttrell LM Ferguson SS Daaka Y Miller WE Maudsley S Della Rocca GJ ve b Beta arrestin dependent formation of beta2 adrenergic receptor Src protein kinase complexes Science 283 5402 January 1999 655 661 doi 10 1126 science 283 5402 655 PMID 9924018 McDonald PH Cote NL Lin FT Premont RT Pitcher JA Lefkowitz RJ Identification of NSF as a beta arrestin1 binding protein Implications for beta2 adrenergic receptor regulation The Journal of Biological Chemistry 274 16 April 1999 10677 10680 doi 10 1074 jbc 274 16 10677 PMID 10196135 Lin FT Miller WE Luttrell LM Lefkowitz RJ Feedback regulation of beta arrestin1 function by extracellular signal regulated kinases The Journal of Biological Chemistry 274 23 June 1999 15971 15974 doi 10 1074 jbc 274 23 15971 PMID 10347142 McConalogue K Dery O Lovett M Wong H Walsh JH Grady EF Bunnett NW Substance P induced trafficking of beta arrestins The role of beta arrestins in endocytosis of the neurokinin 1 receptor The Journal of Biological Chemistry 274 23 June 1999 16257 16268 doi 10 1074 jbc 274 23 16257 PMID 10347182 Miller WE Maudsley S Ahn S Khan KD Luttrell LM Lefkowitz RJ beta arrestin1 interacts with the catalytic domain of the tyrosine kinase c SRC Role of beta arrestin1 dependent targeting of c SRC in receptor endocytosis The Journal of Biological Chemistry 275 15 April 2000 11312 11319 doi 10 1074 jbc 275 15 11312 PMID 10753943 Laporte SA Oakley RH Holt JA Barak LS Caron MG The interaction of beta arrestin with the AP 2 adaptor is required for the clustering of beta 2 adrenergic receptor into clathrin coated pits The Journal of Biological Chemistry 275 30 July 2000 23120 23126 doi 10 1074 jbc M002581200 PMID 10770944 Bennett TA Maestas DC Prossnitz ER Arrestin binding to the G protein coupled N formyl peptide receptor is regulated by the conserved DRY sequence The Journal of Biological Chemistry 275 32 August 2000 24590 24594 doi 10 1074 jbc C000314200 PMID 10823817 Shiina T Kawasaki A Nagao T Kurose H Interaction with beta arrestin determines the difference in internalization behavor between beta1 and beta2 adrenergic receptors The Journal of Biological Chemistry 275 37 September 2000 29082 29090 doi 10 1074 jbc M909757199 PMID 10862778 Barlic J Andrews JD Kelvin AA Bosinger SE DeVries ME Xu L ve b Regulation of tyrosine kinase activation and granule release through beta arrestin by CXCRI Nature Immunology 1 3 September 2000 227 233 doi 10 1038 79767 PMID 10973280 Shukla AK Westfield GH Xiao K Reis RI Huang LY Tripathi Shukla P ve b Visualization of arrestin recruitment by a G protein coupled receptor Nature 512 7513 August 2014 218 222 Bibcode 2014Natur 512 218S doi 10 1038 nature13430 PMC 4134437 PMID 25043026 Xarici kecidler

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