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ARFIP2 və ya Arfaptin-2 — insanlarda ARFIP2 geni ilə kodlanan bir zülal.
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| ARFIP2, POR1, ADP ribosylation factor interacting protein 2 | |||||||||||||||||||||||||
| Xarici ID-lər | 601638 1924182 8234 ARFIP2 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Yeri (UCSC) | Chr 11: 6.47 – 6.48 Mb | Chr 7: 105.28 – 105.29 Mb | |||||||||||||||||||||||
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Qarşılıqlı əlaqələri
ARFIP2-nin qarşılıqlı əlaqələri
- Arf6
- ARF3
- ARF5 və
- RAC1
İstinadlar
- GRCh38: Ensembl release 89: ENSG00000132254 - , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000030881 - , May 2017
- "Human PubMed Reference:".
- "Mouse PubMed Reference:".
- Van Aelst L, Joneson T, Bar-Sagi D. "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). August 1996: 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
- Kanoh H, Williger BT, Exton JH. "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). February 1997: 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
- "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 2010-12-05 tarixində . İstifadə tarixi: 2023-09-21.
- D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
- Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
- Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ. "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). May 2001: 215–9. doi:10.1038/35075620. PMID 11346801.
Ədəbiyyatı
- D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L. "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). September 1997: 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
- Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ. "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). May 2001: 215–9. doi:10.1038/35075620. PMID 11346801.
- Shin OH, Exton JH. "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). August 2001: 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
- Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C. "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3). March 2002: 240–5. doi:10.1038/ncb761. PMID 11854752.
- Lu L, Hong W. "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9). September 2003: 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
- Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S. "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23). June 2005: 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). October 2005: 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
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ARFIP2 ve ya Arfaptin 2 insanlarda ARFIP2 geni ile kodlanan bir zulal ARFIP2Movcud strukturlarOrtoloq axtarisi PDBe RCSBPDB id kodlarinin siyahisi1I49 1I4D 1I4L 1I4T 4DCNTanimlayicilarARFIP2 POR1 ADP ribosylation factor interacting protein 2Xarici ID ler601638 1924182 8234 ARFIP2Genin yeri Insan XromosomLokus11p15 4Baslangic6 474 683Son6 481 479Genin yeri Sican XromosomXromosom 7 sican Lokus7 7 E3Baslangic105 283 410Son105 289 623Ifade melumati ucun daha cox istinadMolekulyar funksiya phosphatidylinositol 4 phosphate binding protein domain specific binding GO 0001948 GO 0016582 protein binding GTP binding identical protein binding cadherin binding GTP dependent protein binding phospholipid bindingHucresel komponent cell cortex trans Golgi network membrane Membran ruffle cytosol SitoplazmaBioloji proses ruffle organization small GTPase mediated signal transduction actin cytoskeleton organization regulation of Arp2 3 complex mediated actin nucleation lamellipodium assembly intracellular protein transportSources Amigo QuickGOSpeciesHumanMouse2364776932ENSG00000132254ENSMUSG00000030881UniProtP53365Q8K221RefSeq mRNA NM 001242854 NM 001242855 NM 001242856 NM 012402NM 029802RefSeq protein NP 001229783 NP 001229784 NP 001229785 NP 036534 NP 001357335NP 001357337 NP 001357338 NP 001357340 NP 001357341 NP 001357342 NP 001363487 NP 001363488 NP 001363489 NP 001363490 NP 001363491 NP 001363492 NP 001363493NP 084078Yeri UCSC Chr 11 6 47 6 48 MbChr 7 105 28 105 29 MbaxtarisiWikidataInsani goster redakte etSicani goster redakte etQarsiliqli elaqeleriARFIP2 nin qarsiliqli elaqeleri Arf6 ARF3 ARF5 ve RAC1IstinadlarGRCh38 Ensembl release 89 ENSG00000132254 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000030881 May 2017 Human PubMed Reference Mouse PubMed Reference Van Aelst L Joneson T Bar Sagi D Identification of a novel Rac1 interacting protein involved in membrane ruffling The EMBO Journal 15 15 August 1996 3778 86 doi 10 1002 j 1460 2075 1996 tb00751 x PMC 452058 PMID 8670882 Kanoh H Williger BT Exton JH Arfaptin 1 a putative cytosolic target protein of ADP ribosylation factor is recruited to Golgi membranes The Journal of Biological Chemistry 272 9 February 1997 5421 9 doi 10 1074 jbc 272 9 5421 PMID 9038142 Entrez Gene ARFIP2 ADP ribosylation factor interacting protein 2 arfaptin 2 2010 12 05 tarixinde Istifade tarixi 2023 09 21 D Souza Schorey C Boshans RL McDonough M Stahl PD Van Aelst L A role for POR1 a Rac1 interacting protein in ARF6 mediated cytoskeletal rearrangements The EMBO Journal 16 17 September 1997 5445 54 doi 10 1093 emboj 16 17 5445 PMC 1170175 PMID 9312003 Shin OH Exton JH Differential binding of arfaptin 2 POR1 to ADP ribosylation factors and Rac1 Biochemical and Biophysical Research Communications 285 5 August 2001 1267 73 doi 10 1006 bbrc 2001 5330 PMID 11478794 Tarricone C Xiao B Justin N Walker PA Rittinger K Gamblin SJ Smerdon SJ The structural basis of Arfaptin mediated cross talk between Rac and Arf signalling pathways Nature 411 6834 May 2001 215 9 doi 10 1038 35075620 PMID 11346801 EdebiyyatiD Souza Schorey C Boshans RL McDonough M Stahl PD Van Aelst L A role for POR1 a Rac1 interacting protein in ARF6 mediated cytoskeletal rearrangements The EMBO Journal 16 17 September 1997 5445 54 doi 10 1093 emboj 16 17 5445 PMC 1170175 PMID 9312003 Tarricone C Xiao B Justin N Walker PA Rittinger K Gamblin SJ Smerdon SJ The structural basis of Arfaptin mediated cross talk between Rac and Arf signalling pathways Nature 411 6834 May 2001 215 9 doi 10 1038 35075620 PMID 11346801 Shin OH Exton JH Differential binding of arfaptin 2 POR1 to ADP ribosylation factors and Rac1 Biochemical and Biophysical Research Communications 285 5 August 2001 1267 73 doi 10 1006 bbrc 2001 5330 PMID 11478794 Peters PJ Ning K Palacios F Boshans RL Kazantsev A Thompson LM Woodman B Bates GP D Souza Schorey C Arfaptin 2 regulates the aggregation of mutant huntingtin protein Nature Cell Biology 4 3 March 2002 240 5 doi 10 1038 ncb761 PMID 11854752 Lu L Hong W Interaction of Arl1 GTP with GRIP domains recruits autoantigens Golgin 97 and Golgin 245 p230 onto the Golgi Molecular Biology of the Cell 14 9 September 2003 3767 81 doi 10 1091 mbc E03 01 0864 PMC 196566 PMID 12972563 Rangone H Pardo R Colin E Girault JA Saudou F Humbert S Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ huntingtin induced toxicity by rescuing proteasome impairment The Journal of Biological Chemistry 280 23 June 2005 22021 8 doi 10 1074 jbc M407528200 PMID 15809304 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 October 2005 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514