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CYTH2 həmçinin sitohesin-2 adlanır — insanlarda CYTH2 geni ilə kodlanan bir zülal.
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| Tanımlayıcılar | |||||||||||||||||||||||||
| CYTH2, ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin 2, cytohesin-2 | |||||||||||||||||||||||||
| Xarici ID-lər | 602488 1334255 32116 CYTH2 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Yeri (UCSC) | Chr 19: 48.47 – 48.48 Mb | Chr 7: 45.46 – 45.46 Mb | |||||||||||||||||||||||
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Funksiyası
Sitohesin-2 (CYTH2), əvvəllər Pleskstrin homologiyası, Sec7 və spiral formalı domenlər 2 (PSCD2) kimi tanınan sitohezin sinfinin üzvüdür. Bu sinfin üzvləri N-terminal spiral formalı motivindən, mərkəzi Sec7 domenindən və C-terminal plekstrin homologiyasından (PH) ibarət olan eyni struktur təşkilata malikdirlər.
Qıvrılmış spiral formalı homodimerləşmədə iştirak edir, Sec7 domeni guanin-nukleotid mübadiləsi zülalının (GEP) aktivliyinə malikdir və PH sahəsi fosfolipidlərlə qarşılıqlı əlaqədə olur və CYTH-nin membranlarla birləşməsindən məsuldur. Bu sinfin üzvləri zülalların çeşidlənməsi və membran hərəkətinin tənzimlənməsində vasitəçilik edirlər.
CYTH2 ARF1, ARF3 və ARF6 ilə in vitro GEP fəaliyyətini nümayiş etdirir. CYTH2 zülalı CYTH1 ilə 83% homoloqdur. Bu gen üçün müxtəlif izoformları kodlayan 2 transkript variantı tapılıb.
Qarşılıqlı əlaqələri
CYTH2-nin arrestin beta 2 və arrestin beta 1 ilə qarşılıqlı əlaqədə olduğu göstərilmişdir.
İstinadlar
- GRCh38: Ensembl release 89: ENSG00000105443 - , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000003269 - , May 2017
- "Human PubMed Reference:".
- "Mouse PubMed Reference:".
- Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B. "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2). Sep 1996: 233–42. doi:10.1016/S0092-8674(00)80095-1. PMID 8706128.
- Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M. "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608). 1996: 481–4. Bibcode:1996Natur.384..481C. doi:10.1038/384481a0. PMID 8945478.
- "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)". 2010-12-05 tarixində . İstifadə tarixi: 2023-09-19.
- "Arxivlənmiş surət". 2023-03-22 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
- Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45). Nov 2001: 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.
Ədəbiyyatı
- Meacci E, Tsai SC, Adamik R, Moss J, Vaughan M. "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor". Proc. Natl. Acad. Sci. U.S.A. 94 (5). 1997: 1745–8. Bibcode:1997PNAS...94.1745M. doi:10.1073/pnas.94.5.1745. PMC 19987. PMID 9050849.
- Frank S, Upender S, Hansen SH, Casanova JE. "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1). 1998: 23–7. doi:10.1074/jbc.273.1.23. PMID 9417041.
- Mossessova E, Gulbis JM, Goldberg J. "Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase". Cell. 92 (3). 1998: 415–23. doi:10.1016/S0092-8674(00)80933-2. PMID 9476900.
- Cherfils J, Ménétrey J, Mathieu M, Le Bras G, Robineau S, Béraud-Dufour S, Antonny B, Chardin P. "Structure of the Sec7 domain of the Arf exchange factor ARNO". Nature. 392 (6671). 1998: 101–5. Bibcode:1998Natur.392..101C. doi:10.1038/32210. PMID 9510256.
- Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ. "Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase". Curr. Biol. 8 (8). 1998: 463–6. doi:10.1016/S0960-9822(98)70181-2. PMID 9550703.
- Kim HS. "Assignment of the human cts18.1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel". Cytogenet. Cell Genet. 83 (1–2). 1998: 43. doi:10.1159/000015163. PMID 9925920.
- Santy LC, Frank SR, Hatfield JC, Casanova JE. "Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch". Curr. Biol. 9 (20). 1999: 1173–6. doi:10.1016/S0960-9822(00)80019-6. PMID 10531036.
- Ogasawara M, Kim SC, Adamik R, Togawa A, Ferrans VJ, Takeda K, Kirby M, Moss J, Vaughan M. "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5). 2000: 3221–30. doi:10.1074/jbc.275.5.3221. PMID 10652308.
- Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB. "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1). 2000: 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
- Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M. "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. 275 (28). 2000: 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.
- Macia E, Paris S, Chabre M. "Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids". Biochemistry. 39 (19). 2000: 5893–901. doi:10.1021/bi992795w. PMID 10801341.
- Lee SY, Pohajdak B. "N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi". J. Cell Sci. 113 (11). 2000: 1883–9. doi:10.1242/jcs.113.11.1883. PMID 10806099.
- Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45). 2001: 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.
- Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4). 2002: 1280–9. doi:10.1523/JNEUROSCI.22-04-01280.2002. PMC 6757580. PMID 11850456.
- Mansour M, Lee SY, Pohajdak B. "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35). 2002: 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
- Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis SE. "Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2". Cytogenet. Genome Res. 97 (3–4). 2002: 171–8. doi:10.1159/000066620. PMID 12438709.
- Huh M, Han JH, Lim CS, Lee SH, Kim S, Kim E, Kaang BK. "Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons". J. Neurochem. 85 (1). 2003: 282–5. doi:10.1046/j.1471-4159.2003.01718.x. PMID 12641750.
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CYTH2 hemcinin sitohesin 2 adlanir insanlarda CYTH2 geni ile kodlanan bir zulal CYTH2Movcud strukturlarOrtoloq axtarisi PDBe RCSBPDB id kodlarinin siyahisi1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21TanimlayicilarCYTH2 ARNO CTS18 CTS18 1 PSCD2 PSCD2L SEC7L Sec7p L Sec7p like cytohesin 2 cytohesin 2Xarici ID ler602488 1334255 32116 CYTH2Genin yeri Insan XromosomLokus19q13 33Baslangic48 469 208Son48 482 314Genin yeri Sican XromosomXromosom 7 sican Lokus7 7 B3Baslangic45 456 061Son45 464 005Ifade melumati ucun daha cox istinadMolekulyar funksiya inositol 1 4 5 trisphosphate binding GO 0001948 GO 0016582 protein binding guanyl nucleotide exchange factor activity lipid bindingHucresel komponent Sitoplazma growth cone Membran cell projection membrane Golgi membrane cytosol adherens junction bicellular tight junction cell junctionBioloji proses regulation of ARF protein signal transduction endocytosis actin cytoskeleton organizationSources Amigo QuickGOSpeciesHumanMouse926619158ENSG00000105443ENSMUSG00000003269UniProtQ99418P63034RefSeq mRNA NM 004228 NM 017457NM 001112701 NM 011181RefSeq protein NP 004219 NP 059431NP 001106171 NP 035311Yeri UCSC Chr 19 48 47 48 48 MbChr 7 45 46 45 46 MbaxtarisiWikidataInsani goster redakte etSicani goster redakte etFunksiyasiSitohesin 2 CYTH2 evveller Pleskstrin homologiyasi Sec7 ve spiral formali domenler 2 PSCD2 kimi taninan sitohezin sinfinin uzvudur Bu sinfin uzvleri N terminal spiral formali motivinden merkezi Sec7 domeninden ve C terminal plekstrin homologiyasindan PH ibaret olan eyni struktur teskilata malikdirler Qivrilmis spiral formali homodimerlesmede istirak edir Sec7 domeni guanin nukleotid mubadilesi zulalinin GEP aktivliyine malikdir ve PH sahesi fosfolipidlerle qarsiliqli elaqede olur ve CYTH nin membranlarla birlesmesinden mesuldur Bu sinfin uzvleri zulallarin cesidlenmesi ve membran hereketinin tenzimlenmesinde vasitecilik edirler CYTH2 ARF1 ARF3 ve ARF6 ile in vitro GEP fealiyyetini numayis etdirir CYTH2 zulali CYTH1 ile 83 homoloqdur Bu gen ucun muxtelif izoformlari kodlayan 2 transkript varianti tapilib Qarsiliqli elaqeleriCYTH2 nin arrestin beta 2 ve arrestin beta 1 ile qarsiliqli elaqede oldugu gosterilmisdir IstinadlarGRCh38 Ensembl release 89 ENSG00000105443 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000003269 May 2017 Human PubMed Reference Mouse PubMed Reference Kolanus W Nagel W Schiller B Zeitlmann L Godar S Stockinger H Seed B Alpha L beta 2 integrin LFA 1 binding to ICAM 1 induced by cytohesin 1 a cytoplasmic regulatory molecule Cell 86 2 Sep 1996 233 42 doi 10 1016 S0092 8674 00 80095 1 PMID 8706128 Chardin P Paris S Antonny B Robineau S Beraud Dufour S Jackson CL Chabre M A human exchange factor for ARF contains Sec7 and pleckstrin homology domains Nature 384 6608 1996 481 4 Bibcode 1996Natur 384 481C doi 10 1038 384481a0 PMID 8945478 Entrez Gene PSCD2 pleckstrin homology Sec7 and coiled coil domains 2 cytohesin 2 2010 12 05 tarixinde Istifade tarixi 2023 09 19 Arxivlenmis suret 2023 03 22 tarixinde arxivlesdirilib Istifade tarixi 2023 09 19 Claing A Chen W Miller WE Vitale N Moss J Premont RT Lefkowitz RJ beta Arrestin mediated ADP ribosylation factor 6 activation and beta 2 adrenergic receptor endocytosis J Biol Chem 276 45 Nov 2001 42509 13 doi 10 1074 jbc M108399200 PMID 11533043 EdebiyyatiMeacci E Tsai SC Adamik R Moss J Vaughan M Cytohesin 1 a cytosolic guanine nucleotide exchange protein for ADP ribosylation factor Proc Natl Acad Sci U S A 94 5 1997 1745 8 Bibcode 1997PNAS 94 1745M doi 10 1073 pnas 94 5 1745 PMC 19987 PMID 9050849 Frank S Upender S Hansen SH Casanova JE ARNO is a guanine nucleotide exchange factor for ADP ribosylation factor 6 J Biol Chem 273 1 1998 23 7 doi 10 1074 jbc 273 1 23 PMID 9417041 Mossessova E Gulbis JM Goldberg J Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase Cell 92 3 1998 415 23 doi 10 1016 S0092 8674 00 80933 2 PMID 9476900 Cherfils J Menetrey J Mathieu M Le Bras G Robineau S Beraud Dufour S Antonny B Chardin P Structure of the Sec7 domain of the Arf exchange factor ARNO Nature 392 6671 1998 101 5 Bibcode 1998Natur 392 101C doi 10 1038 32210 PMID 9510256 Venkateswarlu K Oatey PB Tavare JM Cullen PJ Insulin dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3 kinase Curr Biol 8 8 1998 463 6 doi 10 1016 S0960 9822 98 70181 2 PMID 9550703 Kim HS Assignment of the human cts18 1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel Cytogenet Cell Genet 83 1 2 1998 43 doi 10 1159 000015163 PMID 9925920 Santy LC Frank SR Hatfield JC Casanova JE Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch Curr Biol 9 20 1999 1173 6 doi 10 1016 S0960 9822 00 80019 6 PMID 10531036 Ogasawara M Kim SC Adamik R Togawa A Ferrans VJ Takeda K Kirby M Moss J Vaughan M Similarities in function and gene structure of cytohesin 4 and cytohesin 1 guanine nucleotide exchange proteins for ADP ribosylation factors J Biol Chem 275 5 2000 3221 30 doi 10 1074 jbc 275 5 3221 PMID 10652308 Smith JS Tachibana I Pohl U Lee HK Thanarajasingam U Portier BP Ueki K Ramaswamy S Billings SJ Mohrenweiser HW Louis DN Jenkins RB A transcript map of the chromosome 19q arm glioma tumor suppressor region Genomics 64 1 2000 44 50 doi 10 1006 geno 1999 6101 PMID 10708517 Vitale N Pacheco Rodriguez G Ferrans VJ Riemenschneider W Moss J Vaughan M Specific functional interaction of human cytohesin 1 and ADP ribosylation factor domain protein ARD1 J Biol Chem 275 28 2000 21331 9 doi 10 1074 jbc M909642199 PMID 10748148 Macia E Paris S Chabre M Binding of the PH and polybasic C terminal domains of ARNO to phosphoinositides and to acidic lipids Biochemistry 39 19 2000 5893 901 doi 10 1021 bi992795w PMID 10801341 Lee SY Pohajdak B N terminal targeting of guanine nucleotide exchange factors GEF for ADP ribosylation factors ARF to the Golgi J Cell Sci 113 11 2000 1883 9 doi 10 1242 jcs 113 11 1883 PMID 10806099 Claing A Chen W Miller WE Vitale N Moss J Premont RT Lefkowitz RJ beta Arrestin mediated ADP ribosylation factor 6 activation and beta 2 adrenergic receptor endocytosis J Biol Chem 276 45 2001 42509 13 doi 10 1074 jbc M108399200 PMID 11533043 Kitano J Kimura K Yamazaki Y Soda T Shigemoto R Nakajima Y Nakanishi S Tamalin a PDZ domain containing protein links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins J Neurosci 22 4 2002 1280 9 doi 10 1523 JNEUROSCI 22 04 01280 2002 PMC 6757580 PMID 11850456 Mansour M Lee SY Pohajdak B The N terminal coiled coil domain of the cytohesin ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP J Biol Chem 277 35 2002 32302 9 doi 10 1074 jbc M202898200 PMID 12052827 Buchet Poyau K Mehenni H Radhakrishna U Antonarakis SE Search for the second Peutz Jeghers syndrome locus exclusion of the STK13 PRKCG KLK10 and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2 Cytogenet Genome Res 97 3 4 2002 171 8 doi 10 1159 000066620 PMID 12438709 Huh M Han JH Lim CS Lee SH Kim S Kim E Kaang BK Regulation of neuritogenesis and synaptic transmission by msec7 1 a guanine nucleotide exchange factor in cultured Aplysia neurons J Neurochem 85 1 2003 282 5 doi 10 1046 j 1471 4159 2003 01718 x PMID 12641750 Xarici kecidler